Reaction Details Report a problem with these data
Target
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Ligand
BDBM119074
Substrate
n/a
IC50
2.8e+3±n/a nM
Citation
 Hrast, M; Sosic, I; Sink, R; Gobec, S Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F. Bioorg Chem 55:2-15 (2014) [PubMed]  Article 
Target
Name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Synonyms:
MURA_HAEI8 | MurA (H. influenzae) | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | murA
Type:
Protein
Mol. Mass.:
45434.56
Organism:
Haemophilus influenzae (G-proteobacteria)
Description:
H. influenzae MurA
Residue:
424
Sequence:
MDKFRVYGQSRLSGSVNISGAKNAALPILFAAILATEPVKLTNVPELKDIETTLNILRQLGVIANRDETGAVLLDASNINHFTAPYELVKTMRASIWALAPLVARFHQAQVSLPGGCSIGARPVDLHISGLEKLGADIVLEEGYVKAQVSDRLVGTRIVIEKVSVGATLSIMMAATLAKGTTVIENAAREPEIVDTADFLNKMGAKITGAGSDHITTEGVERLTGCEHSIVPDRIETGTFLIAAAISGGRVVCQNTKADTLDAVIDKLREAGAQVDVTENSITLDMLGNRPKAVNIRTAPHPGFPTDMQAQFTLLNMVAEGTSIITETIFENRFMHIPELIRMGGKAEIEGNTAVCHGVEQLSGTEVIATDLRASISLVLAGCIATGETIVDRIYHIDRGYEHIEDKLRALGAKIERFSRSDEA
  
Inhibitor
Name:
BDBM119074
Synonyms:
MurA inhibitor (compound 11)
Type:
Small organic molecule
Emp. Form.:
C15H8ClNO4
Mol. Mass.:
301.681
SMILES:
Oc1ccc(OC2=C(Cl)C(=O)c3ncccc3C2=O)cc1 |c:6|
Structure:
Search PDB for entries with ligand similarity: