Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM119703
Substrate
n/a
Meas. Tech.
Enzyme Assay
Temperature
303.15±n/a K
IC50
148±n/a nM
Comments
extracted
Citation
 Cossío Mora, FP; Zubia Olascoaga, A; Vara Salazar, Y; San Sebastián Larzabal, EI; Otaegui Ansa, D; Masdeu Margalef, M; Aldaba Arévalo, E Histone deacetylase inhibitors based simultaneously on trisubstituted 1H-pyrroles and aromatic and heteroaromatic spacers US Patent  US8685992 Publication Date 4/1/2014 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM119703
Synonyms:
US8685992, 27
Type:
Small organic molecule
Emp. Form.:
C24H21N3O5
Mol. Mass.:
431.4406
SMILES:
COc1ccc(cc1)-c1cc(-c2ccoc2)c([nH]1)C(=O)NCc1ccc(cc1)C(=O)NO
Structure:
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