Reaction Details Report a problem with these data
Target
Enoyl-acyl carrier reductase ENR
Ligand
BDBM50435717
Substrate
n/a
Meas. Tech.
TgENR Inhibition Assay
pH
7.5±n/a
IC50
19±0.0 nM
Comments
extracted
Citation
 Afanador, GA; Muench, SP; McPhillie, M; Fomovska, A; Schön, A; Schön, Y; Cheng, G; Stec, J; Freundlich, JS; Shieh, HM; Anderson, JW; Jacobus, DP; Fidock, DA; Kozikowski, AP; Fishwick, CW; Rice, DW; Freire, E; McLeod, R; Prigge, ST Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay. Biochemistry 52:9155-66 (2013) [PubMed]  Article 
Target
Name:
Enoyl-acyl carrier reductase ENR
Synonyms:
Enoyl-acyl carrier reductase | Enoyl-acyl carrier reductase (ENR) | Enoyl-acyl carrier reductase, putative
Type:
PROTEIN
Mol. Mass.:
43663.67
Organism:
Toxoplasma gondii
Description:
ChEMBL_1290812
Residue:
417
Sequence:
MVGFKLLTLGAFVAGELTLVGPAGTMAFTVPNATGAKPLVTSVSVRPSWSSARQNAFSSSSSRSQSSVRPHSAFVTNRLETAGETGTQHRAADSAAGVGAAQSAFPIDLRGQTAFVAGVADSHGYGWAIAKHLASAGARVALGTWPPVLGLFQKSLQSGRLDEDRKLPDGSLIEFAGVYPLDAAFDKPEDVPQDIKDNKRYAGVDGYTIKEVAVKVKQDLGNIDILVHSLANGPEVTKPLLETSRKGYLAASSNSAYSFVSLLQHFGPIMNEGGSAVTLSYLAAERVVPGYGGGMSSAKAALESDTRTLAWEAGQKYGVRVNAISAGPLKSRAASAIGKSGEKSFIDYAIDYSYNNAPLRRDLHSDDVGGAALFLLSPLARAVSGVTLYVDNGLHAMGQAVDSRSMPPLQRATQEIN
  
Inhibitor
Name:
BDBM50435717
Synonyms:
CHEMBL2392450 | N‐{[4‐(2,4‐dichlorophenoxy)‐3‐ hydroxyphenyl]methyl}‐5‐methyl‐1,2‐oxazole‐3‐ carboxamide (27)
Type:
Small organic molecule
Emp. Form.:
C18H14Cl2N2O4
Mol. Mass.:
393.221
SMILES:
Cc1cc(no1)C(=O)NCc1ccc(Oc2ccc(Cl)cc2Cl)c(O)c1
Structure:
Search PDB for entries with ligand similarity: