Reaction Details Report a problem with these data
Target
Trace amine-associated receptor 1
Ligand
BDBM283791
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay on Rat TAAR1
pH
7.4±n/a
Ki
1.60±n/a nM
Comments
extracted
Citation
 Cecere, G; Galley, G; Norcross, R; Pflieger, P; Rauber, E Substituted azetidine derivatives US Patent  US10023559 Publication Date 7/17/2018 
Target
Name:
Trace amine-associated receptor 1
Synonyms:
TAAR1_RAT | Ta1 | Taar1 | Tar1 | Trace amine receptor 1 (TARR1) | Trace amine-associated receptor 1 | Trace amine-associated receptor 1 (TAAR1) | Trace amine-associated receptor1 | Trar1
Type:
Enzyme
Mol. Mass.:
38034.73
Organism:
Rattus norvegicus (Rat)
Description:
Q923Y9
Residue:
332
Sequence:
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
  
Inhibitor
Name:
BDBM283791
Synonyms:
1-[4-(azetidin-3-ylidenemethyl)phenyl]-3-[4-(trifluoromethyl)phenyl]urea | US10023559, Example 116
Type:
Small organic molecule
Emp. Form.:
C18H16F3N3O
Mol. Mass.:
347.3343
SMILES:
FC(F)(F)c1ccc(-[#7]-[#6](=O)-[#7]-c2ccc(\[#6]=[#6]-3/[#6]-[#7]-[#6]-3)cc2)cc1
Structure:
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