Reaction Details Report a problem with these data
Target
Prokineticin receptor 1
Ligand
BDBM121281
Substrate
n/a
Meas. Tech.
Calcium Mobilization Assay
Temperature
310.15±n/a K
Ki
5.46±n/a nM
Comments
extracted
Citation
 Zhou, Q; Li, J; Huang, Q Prokineticin receptor antagonists and uses thereof US Patent  US8722896 Publication Date 5/13/2014 
Target
Name:
Prokineticin receptor 1
Synonyms:
Prokineticin receptor 1 (PRK1)
Type:
Enzyme
Mol. Mass.:
44908.29
Organism:
Cricetulus griseus (Chinese hamster)
Description:
G3HIE5
Residue:
399
Sequence:
MPPPAWMEPTVGALGENTTDTSTSFLSLVNARGAQAASFPFTLSYGDYDTALGEEEDVTKSWTFFAARIVIGMALVAIMLVCGVGNFIFITTLARYKKLRNLTNLLIANLAISDFLVAIVCCPFEMDYYVVRQLSWEHGHVLCASVNYLRTVSLYVSTNALLAIAIDRYLAIVHPLRPRMKCQTAAGLIFLVWSVSILIAIPAAYFTTETVLVIVESQEKIFCGQIWPVDQQVYYRSYFLLVFGLEFVGPVVAMTLCYARVSRELWFKAVPGFQTEQIRRRLRCRRRTVLGLVCVLSAYVLCWAPFYGFTIVRDFFPSVFVKEKHYLTAFYVVECIAMSNSMINTLCFVSVRNNTSKYLKRILRLQWRASPSGSKASADLDLRTTGMPATEEVDCIGLK
  
Inhibitor
Name:
BDBM121281
Synonyms:
US8722896, (+/-)-4-(2,3-Dihydro-1- benzofuran-7-ylmethyl)-N-(9- chloro-3,4-dihydro-2H-1,5- benzodioxepin-7-ylmethyl)-N- isobutylmorpholine-2- carboxamide
Type:
Small organic molecule
Emp. Form.:
C28H35ClN2O5
Mol. Mass.:
515.041
SMILES:
CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CN(Cc2cccc3CCOc23)CCO1
Structure:
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