Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 8 [1-363]
Ligand
BDBM103302
Substrate
n/a
Meas. Tech.
Selectivity screening
IC50
1080±0.0 nM
Citation
 Chaikuad, A; Tacconi, EM; Zimmer, J; Liang, Y; Gray, NS; Tarsounas, M; Knapp, S A unique inhibitor binding site in ER K1/2 is associated with slow binding kinetics Nat Chem Biol 10:853-860 (2014) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 8 [1-363]
Synonyms:
JNK1 | MAPK8 | MK08_HUMAN | PRKM8 | SAPK1 | SAPK1C | c-Jun N-terminal kinase 1 truncation (JNK1) (aa 1-363)
Type:
Protein
Mol. Mass.:
41916.24
Organism:
Homo sapiens (Human)
Description:
JNK1 truncation 1-363aa (curated by PDB 4QTD)
Residue:
363
Sequence:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDL
  
Inhibitor
Name:
BDBM103302
Synonyms:
SCH772984 | US8546404, 6
Type:
Small organic molecule
Emp. Form.:
C33H33N9O2
Mol. Mass.:
587.6742
SMILES:
O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1 |r|
Structure:
Search PDB for entries with ligand similarity: