Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM123101
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7±n/a
Ki
0.6±n/a nM
Comments
extracted
Citation
 Odén, LS; Nilsson, M; Kahnberg, P; Samuelsson, B; Grabowska, U Protease inhibitors US Patent  US8735395 Publication Date 5/27/2014 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM123101
Synonyms:
US11312693, Example 5 | US8735395, 5
Type:
Small organic molecule
Emp. Form.:
C30H34FN5O4S
Mol. Mass.:
579.685
SMILES:
CN1CCN(CC1)c1nc(c(F)s1)-c1ccc(cc1)C(=O)N[C@@H](C1CCCC1)C(=O)N1C[C@@H](C#C)[C@H]2OCC(=O)[C@@H]12 |r|
Structure:
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