Reaction Details Report a problem with these data
Target
Histamine H3 receptor
Ligand
BDBM126004
Substrate
n/a
Meas. Tech.
Functional Assay
Ki
0.9±0.0 nM
Citation
 Dorwald, FZ; Hohlweg, R; Christensen, IT; Lundbeck, JM; Andersen, KE Benzothiazoles having histamine H3 receptor activity US Patent  US8772285 Publication Date 7/8/2014 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM126004
Synonyms:
US8772285, 27
Type:
Small organic molecule
Emp. Form.:
C18H24N4S
Mol. Mass.:
328.475
SMILES:
C(NC1CC1)c1ccc2nc(sc2c1)N1CCN(CC1)C1CC1
Structure:
Search PDB for entries with ligand similarity: