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Target
Cyclin-T1
Ligand
BDBM126245
Substrate
n/a
Meas. Tech.
IMAP Assay
IC50
0.007945±n/a nM
Citation
 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent  US8778951 Publication Date 7/15/2014 
Target
Name:
Cyclin-T1
Synonyms:
CCNT1 | CCNT1_HUMAN | CycT | CycT1 | Cyclin T | Cyclin T1 | Cyclin-T
Type:
Enzyme Subunit
Mol. Mass.:
80712.40
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
726
Sequence:
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK
  
Inhibitor
Name:
BDBM126245
Synonyms:
US8778951, 55
Type:
Small organic molecule
Emp. Form.:
C23H27ClN6
Mol. Mass.:
422.954
SMILES:
NC[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccnc2)n1 |r,wU:5.8,wD:2.1,(6,2.69,;4.67,1.93,;3.33,2.69,;3.33,4.23,;2,5,;.67,4.23,;.67,2.69,;2,1.93,;-.67,5,;-2,4.23,;-2,2.69,;-3.33,1.93,;-4.67,2.69,;-6,1.93,;-4.67,4.23,;-3.33,5,;-3.33,.38,;-4.67,-.38,;-4.67,-1.93,;-3.33,-2.69,;-2,-1.93,;-.67,-2.69,;.67,-1.93,;2,-2.69,;2,-4.23,;3.33,-5,;4.67,-4.23,;4.67,-2.69,;3.33,-1.92,;-2,-.38,)|
Structure:
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