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Target
Cyclin-T1
Ligand
BDBM126511
Substrate
n/a
Meas. Tech.
IMAP Assay
IC50
0.003±n/a nM
Citation
 Barsanti, PA; Hu, C; Jin, J; Keyes, R; Kucejko, R; Lin, X; Pan, Y; Pfister, KB; Sendzik, M; Sutton, J; Wan, L Heteroaryl compounds and their uses US Patent  US8778951 Publication Date 7/15/2014 
Target
Name:
Cyclin-T1
Synonyms:
CCNT1 | CCNT1_HUMAN | CycT | CycT1 | Cyclin T | Cyclin T1 | Cyclin-T
Type:
Enzyme Subunit
Mol. Mass.:
80712.40
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
726
Sequence:
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK
  
Inhibitor
Name:
BDBM126511
Synonyms:
US8778951, 322
Type:
Small organic molecule
Emp. Form.:
C26H35ClFN5O3S
Mol. Mass.:
552.104
SMILES:
Fc1ccc(nc1NCC1CCOCC1)-c1cc(N[C@H]2CC[C@@H](CC2)NC2CCS(=O)(=O)C2)ncc1Cl |r,wU:19.20,wD:22.27,(-5.19,-4.23,;-5.19,-2.69,;-6.52,-1.93,;-6.52,-.38,;-5.19,.38,;-3.85,-.38,;-3.85,-1.93,;-2.52,-2.69,;-1.18,-1.93,;.15,-2.69,;.15,-4.23,;1.48,-5,;2.82,-4.23,;2.82,-2.69,;1.48,-1.92,;-5.19,1.93,;-3.85,2.69,;-3.85,4.23,;-2.52,5,;-1.18,4.23,;.15,5,;1.48,4.23,;1.48,2.69,;.15,1.93,;-1.18,2.69,;2.82,1.93,;4.15,2.69,;4.15,4.23,;5.61,4.71,;6.52,3.47,;7.85,4.23,;7.85,2.69,;5.61,2.22,;-5.19,5,;-6.52,4.23,;-6.52,2.69,;-7.85,1.93,)|
Structure:
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