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Target
Prostaglandin D2 receptor 2
Ligand
BDBM127150
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
pH
7.4±n/a
Ki
0.8±n/a nM
Comments
extracted
Citation
 Oost, T; Anderskewitz, R; Hamprecht, DW; Hoenke, C; Martyres, D; Rist, W; Seither, P Pyrazole compounds as CRTH2 antagonists US Patent  US8791272 Publication Date 7/29/2014 
Target
Name:
Prostaglandin D2 receptor 2
Synonyms:
CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:
Enzyme
Mol. Mass.:
43295.45
Organism:
Homo sapiens (Human)
Description:
Q9Y5Y4
Residue:
395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
  
Inhibitor
Name:
BDBM127150
Synonyms:
US8791272, 2.33
Type:
Small organic molecule
Emp. Form.:
C27H35N3O3
Mol. Mass.:
449.5851
SMILES:
CCc1nn(Cc2ccc(NC(=O)C3[C@H]4C[C@@H]5C[C@@H](C[C@H]3C5)C4)cc2)c(CC)c1CC(O)=O |r,wU:16.22,14.24,wD:18.17,20.21,(1.28,4.24,;2.77,4.64,;3.86,3.55,;3.38,2.09,;4.63,1.18,;4.63,-.36,;3.3,-1.13,;1.96,-.36,;.63,-1.13,;.63,-2.67,;-.71,-3.44,;-2.04,-2.67,;-2.04,-1.13,;-3.37,-3.44,;-4.7,-3.06,;-6.38,-4.77,;-6.67,-6.13,;-7.07,-4.64,;-5.98,-3.55,;-4.49,-3.95,;-4.1,-5.43,;-5.19,-6.52,;-5.23,-1.62,;1.96,-3.44,;3.3,-2.67,;5.87,2.09,;7.36,1.69,;7.76,.2,;5.4,3.55,;6.49,4.64,;6.09,6.13,;7.18,7.22,;4.6,6.53,)|
Structure:
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