Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128226
Substrate
n/a
Meas. Tech.
Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7
IC50
>167158±n/a nM
Citation
 PubChem, PC Counterscreen for activators of Transthyretin (TTR) transcription: Luminescence-based cell-based high throughput dose response assay to identify inhibitors of Transthyretin (TTR) transcription in HuH7 hepatoma cells PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128226
Synonyms:
1-(5-acetyl-2,6-dimethyl-3-pyridinyl)ethanone | 1-(5-acetyl-2,6-dimethyl-3-pyridyl)ethanone | 1-(5-acetyl-2,6-dimethylpyridin-3-yl)ethanone | 1-(5-ethanoyl-2,6-dimethyl-pyridin-3-yl)ethanone | MLS000765927 | SMR000279633 | cid_540145
Type:
Small organic molecule
Emp. Form.:
C11H13NO2
Mol. Mass.:
191.2264
SMILES:
CC(=O)c1cc(C(C)=O)c(C)nc1C
Structure:
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