Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM128221
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription
EC50
>167158±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM128221
Synonyms:
(1,5-dimethylpyrazol-4-yl)-indolin-1-yl-methanone | 1-[(1,5-dimethyl-1H-pyrazol-4-yl)carbonyl]indoline | 2,3-dihydroindol-1-yl-(1,5-dimethyl-4-pyrazolyl)methanone | 2,3-dihydroindol-1-yl-(1,5-dimethylpyrazol-4-yl)methanone | MLS000698295 | SMR000227824 | cid_1225706
Type:
Small organic molecule
Emp. Form.:
C14H15N3O
Mol. Mass.:
241.2884
SMILES:
Cc1c(cnn1C)C(=O)N1CCc2ccccc12
Structure:
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