Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM69068
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription
EC50
>167158±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify activators of Transthyretin (TTR) transcription PubChem Bioassay (2014)[AID] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM69068
Synonyms:
(4-bromanyl-2,5-dimethyl-pyrazol-3-yl)-(2,3-dihydroindol-1-yl)methanone | (4-bromo-2,5-dimethyl-3-pyrazolyl)-(2,3-dihydroindol-1-yl)methanone | (4-bromo-2,5-dimethyl-pyrazol-3-yl)-indolin-1-yl-methanone | (4-bromo-2,5-dimethylpyrazol-3-yl)-(2,3-dihydroindol-1-yl)methanone | 1-[(4-bromo-1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]indoline | MLS000698064 | SMR000228334 | cid_844740
Type:
Small organic molecule
Emp. Form.:
C14H14BrN3O
Mol. Mass.:
320.184
SMILES:
Cc1nn(C)c(C(=O)N2CCc3ccccc23)c1Br
Structure:
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