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Target
Cyclin-dependent kinase 1
Ligand
BDBM129358
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
8±n/a
Temperature
295.15±n/a K
IC50
>1000±n/a nM
Comments
extracted
Citation
 Lücking, U; Siemeister, G; Lienau, P; Jautelat, R; Schulze, J Sulfone-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as a medicine US Patent  US8802686 Publication Date 8/12/2014 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM129358
Synonyms:
US8802686, 16
Type:
Small organic molecule
Emp. Form.:
C18H20F3N3O3S
Mol. Mass.:
415.43
SMILES:
CS(=O)(=O)c1ccc(Nc2ncc(c(OC3CCCCC3)n2)C(F)(F)F)cc1
Structure:
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