Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM130511
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
2±n/a nM
Citation
 Winters, MP; Fawzy, NE; Kang, F; Sui, Z Fused cyclopentyl antagonists of CCR2 US Patent  US8822460 Publication Date 9/2/2014 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM130511
Synonyms:
US8822460, 7 | US8822460, 9
Type:
Small organic molecule
Emp. Form.:
C24H31F3N2O4
Mol. Mass.:
468.5091
SMILES:
COC1COCCC1NC1CC2OCCC2(C1)C(=O)N1CCc2ccc(cc2C1)C(F)(F)F
Structure:
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