Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50352675
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
IC50
200±n/a nM
Comments
extracted
Citation
 Lee, J; Seo, HJ; Kang, SY; Park, E; Kim, MJ; Lee, SH; Kim, JY; Kim, J; Jung, ME; Kim, HJ; Kim, M; Han, HK; Ahn, KW; Lee, MW; Lee, K; Pae, AN; Park, W Arylpiperazine-containing imidazole 4-carboxamide derivatives and pharmaceutical composition comprising same US Patent  US8835436 Publication Date 9/16/2014 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50352675
Synonyms:
CHEMBL1823089 | US8835436, Example 101
Type:
Small organic molecule
Emp. Form.:
C27H34ClN5O
Mol. Mass.:
480.045
SMILES:
Cc1nc(C(=O)NCCCN2CCN(CC2)c2cccc(C)c2C)c(C)n1-c1ccccc1Cl |(16.51,-45.78,;17.28,-44.45,;18.82,-44.45,;19.3,-42.99,;20.64,-42.22,;20.64,-40.68,;21.97,-42.99,;23.3,-42.22,;24.64,-42.99,;25.97,-42.22,;27.3,-42.98,;28.62,-42.2,;29.95,-42.97,;29.96,-44.51,;28.63,-45.28,;27.29,-44.52,;31.29,-45.27,;32.63,-44.49,;33.96,-45.26,;33.97,-46.8,;32.63,-47.57,;32.63,-49.11,;31.3,-46.81,;29.96,-47.58,;18.05,-42.08,;18.05,-40.54,;16.81,-42.99,;15.48,-42.21,;15.48,-40.67,;14.15,-39.9,;12.81,-40.67,;12.81,-42.22,;14.15,-42.98,;14.15,-44.52,)|
Structure:
Search PDB for entries with ligand similarity: