Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 5A
Ligand
BDBM135785
Substrate
n/a
Meas. Tech.
Binding Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
1.3±n/a nM
Comments
extracted
Citation
 Kinoyama, I; Miyazaki, T; Koganemaru, Y; Washio, T; Hamaguchi, W Nitrogenous-ring acylguanidine derivative US Patent  US8853242 Publication Date 10/7/2014 
Target
Name:
5-hydroxytryptamine receptor 5A
Synonyms:
5-HT-5 | 5-HT-5A | 5-hydroxytryptamine receptor 5 (5-HT5) | 5-hydroxytryptamine receptor 5A (5-HT5A) | 5HT5A_HUMAN | HTR5A | Serotonin (5-HT) receptor | Serotonin receptor 5A
Type:
Enzyme
Mol. Mass.:
40266.25
Organism:
Homo sapiens (Human)
Description:
P47898
Residue:
357
Sequence:
MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
  
Inhibitor
Name:
BDBM135785
Synonyms:
US8853242, 152
Type:
Small organic molecule
Emp. Form.:
C18H13F3N4O
Mol. Mass.:
358.3172
SMILES:
Cc1cnc(-c2c(F)cc(F)cc2F)c2cc(ccc12)C(=O)N=C(N)N |(-.38,-4.67,;-1.15,-3.33,;-2.69,-3.33,;-3.46,-2,;-2.69,-.67,;-3.47,.67,;-5,.67,;-5.78,-.67,;-5.78,2,;-5,3.33,;-5.78,4.67,;-3.47,3.33,;-2.69,2,;-1.15,2,;-1.15,-.67,;-.38,.67,;1.15,.67,;1.93,-.67,;1.15,-2,;-.38,-2,;1.93,2,;1.15,3.33,;3.47,2,;4.23,3.33,;5.78,3.33,;3.47,4.67,)|
Structure:
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