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Target
Proteinase-activated receptor 1
Ligand
BDBM135844
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.5±n/a
IC50
132±n/a nM
Comments
extracted
Citation
 Heinelt, U; Wehner, V; Herrmann, M; Schoenafinger, K; Steinhagen, H Triazolium salts as PAR1 inhibitors, production thereof, and use as medicaments US Patent  US8853206 Publication Date 10/7/2014 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM135844
Synonyms:
US8853206, 35
Type:
Small organic molecule
Emp. Form.:
C26H36N5O3
Mol. Mass.:
466.5952
SMILES:
CCC(CC)Oc1ccc2[n+](CC(=O)c3cc(OCC4CC4)cc(c3)C(C)(C)C)nc(N)n2n1
Structure:
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