Reaction Details Report a problem with these data
Target
Dipeptidyl peptidase 1
Ligand
BDBM139515
Substrate
n/a
Meas. Tech.
Inhbition Assay
Temperature
298.15±n/a K
IC50
500.9±n/a nM
Comments
extracted
Citation
 Grauert, M; Anderskewitz, R; Grundl, M; Oost, T; Pautsch, A; Peters, S Substituted bicyclic 1-carboxylic-acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C US Patent  US8889708 Publication Date 11/18/2014 
Target
Name:
Dipeptidyl peptidase 1
Synonyms:
CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI)
Type:
Enzyme
Mol. Mass.:
51857.28
Organism:
Homo sapiens (Human)
Description:
P53634
Residue:
463
Sequence:
MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
  
Inhibitor
Name:
BDBM139515
Synonyms:
US8889708, 13
Type:
Small organic molecule
Emp. Form.:
C25H26N4O2
Mol. Mass.:
414.4995
SMILES:
CN1Cc2cc(ccc2C1=O)-c1ccc(C[C@H](NC(=O)[C@@]23CC[C@H](CN2)C3)C#N)cc1 |r|
Structure:
Search PDB for entries with ligand similarity: