Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM141344
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
0.22±n/a nM
Citation
 Hayashi, K; Tamura, Y; Omori, N 5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity US Patent  US8916594 Publication Date 12/23/2014 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY5R_MOUSE | Neuropeptide Y receptor Y5 | Neuropeptide Y receptor type 5 (NPY Y5) | Npy5 | Npy5r
Type:
Enzyme
Mol. Mass.:
52807.91
Organism:
Mus musculus (Mouse)
Description:
O70342
Residue:
466
Sequence:
MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDDLQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSYSFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVKPEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS
  
Inhibitor
Name:
BDBM141344
Synonyms:
US8916594, I-017
Type:
Small organic molecule
Emp. Form.:
C17H23FN4O3S
Mol. Mass.:
382.453
SMILES:
CCS(=O)(=O)NC[C@H]1CC[C@@H](CC1)Nc1nc(no1)-c1cccc(F)c1 |r,wU:7.6,wD:10.13,(-9.5,.87,;-8.16,.1,;-6.83,.87,;-7.6,2.21,;-6.06,2.21,;-5.5,.1,;-4.16,.87,;-2.83,.1,;-1.49,.87,;-.16,.1,;-.16,-1.44,;-1.49,-2.21,;-2.83,-1.44,;1.17,-2.21,;2.51,-1.44,;3.97,-1.91,;4.88,-.67,;3.97,.58,;2.51,.1,;6.42,-.67,;7.19,-2,;8.73,-2,;9.5,-.67,;8.73,.67,;9.5,2,;7.19,.67,)|
Structure:
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