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Target
EF-hand calcium-binding domain-containing protein 4B
Ligand
BDBM141440
Substrate
n/a
Meas. Tech.
In-Vitro Inhibition Assay
Temperature
310.15±n/a K
IC50
70.32±n/a nM
Comments
extracted
Citation
 Muthuppalaniappan, M; Viswanadha, S; Merikapudi, GS; Vakkalanka, SK Modulators of calcium release-activated calcium channel US Patent  US8921364 Publication Date 12/30/2014 
Target
Name:
EF-hand calcium-binding domain-containing protein 4B
Synonyms:
CRACR2A | Calcium release-activated calcium (CRAC) | EFC4B_HUMAN | EFCAB4B | RAB46
Type:
Protein
Mol. Mass.:
45570.29
Organism:
Homo sapiens (Human)
Description:
Q9BSW2
Residue:
731
Sequence:
MAAPDGRVVSRPQRLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARKDMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAGEQVAQRHEEKVYLSRGDEDLGDMGEDEEAQFRMLMDRLGAQKVLEDESDVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLYEEMEQQIKSEKEQFLLKDTERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQCTALHHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEACKLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERDICFQKNKAAKANTAASRASWKKRSGSVIGKYVDSRGILRSQSEEEEEVFGIPRRSSLGLSGYPLTEEEPGTGEPGPGGPYPRPLRRIISVEEDPLPQLLDGGFEQPLSKCSEEEEVSDQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCKEESSPSAPDRLFKIVFVGNSAVGKTSFLRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQVALQLWDTAGQERYRCITQQFFRKADGVIVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVLLLGNKLDNEKEREVPRGLGEQLATENNLIFYECSAYSGHNTKESLLHLARFLKEQEDTVREDTIQVGHPAKKKSCCG
  
Inhibitor
Name:
BDBM141440
Synonyms:
US10668051, Compound Example 107 | US8921364, 107
Type:
Small organic molecule
Emp. Form.:
C19H13F5N4O
Mol. Mass.:
408.3247
SMILES:
Fc1cccc(C(=O)Nc2ccc(nc2)-n2nc(cc2C2CC2)C(F)(F)F)c1F
Structure:
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