Reaction Details
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Microtubule-associated protein tau
Ligand
BDBM142850
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
6.5±n/a
Temperature
298.15±n/a K
IC50
10.1±n/a nM
Comments
extracted
Citation
Sakai, D; Nakayama, K; Watanabe, K Pyrimidone compounds US Patent US8940738 Publication Date 1/27/2015 More Info.:
Target
Name:
Microtubule-associated protein tau
Synonyms:
MAPT | TAU | TAU_BOVIN | Tau Protein Kinase 1 (TPK1)
Type:
Protein
Mol. Mass.:
46340.02
Organism:
Bos taurus (Bovine)
Description:
P29172
Residue:
448
Sequence:
MAEPRQEFDVMEDHAQGDYTLQDQEGDMDPGLKESPLQTPADDGSEEPGSETSDAKSTPTAEDATAPLVDEGAPGEQAAAQAPAEIPEGTAAEEAGIGDTSNLEDQAAGHVTQARMVSKGKDGTGPDDKKTKGADGKPGTKIATPRGAAPPGQKGQANATRIPAKTTPTPKTSPATMQVQKKPPPAGAKSERGESGKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSAAKSRLQAAPGPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Inhibitor
Name:
BDBM142850
Synonyms:
US8940738, 6
Type:
Small organic molecule
Emp. Form.:
C20H18FN7O
Mol. Mass.:
391.4016
SMILES:
Cn1c(nc(cc1=O)-c1ncncc1F)N1CCNC(C1)c1ccc(cc1)[N+]#[C-]
Structure:
