Reaction Details
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Microtubule-associated protein tau
Ligand
BDBM142851
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
6.5±n/a
Temperature
298.15±n/a K
IC50
78.3±n/a nM
Comments
extracted
Citation
Sakai, D; Nakayama, K; Watanabe, K Pyrimidone compounds US Patent US8940738 Publication Date 1/27/2015 More Info.:
Target
Name:
Microtubule-associated protein tau
Synonyms:
MAPT | TAU | TAU_BOVIN | Tau Protein Kinase 1 (TPK1)
Type:
Protein
Mol. Mass.:
46340.02
Organism:
Bos taurus (Bovine)
Description:
P29172
Residue:
448
Sequence:
MAEPRQEFDVMEDHAQGDYTLQDQEGDMDPGLKESPLQTPADDGSEEPGSETSDAKSTPTAEDATAPLVDEGAPGEQAAAQAPAEIPEGTAAEEAGIGDTSNLEDQAAGHVTQARMVSKGKDGTGPDDKKTKGADGKPGTKIATPRGAAPPGQKGQANATRIPAKTTPTPKTSPATMQVQKKPPPAGAKSERGESGKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSAAKSRLQAAPGPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Inhibitor
Name:
BDBM142851
Synonyms:
US8940738, 7
Type:
Small organic molecule
Emp. Form.:
C21H23FN6O
Mol. Mass.:
394.4453
SMILES:
Cc1cccc(N2CCN(CC2)c2nc(cc(=O)n2C)-c2ncncc2F)c1C
Structure:
