Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM143761
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
692±n/a nM
Citation
 Gelin, CF; Lebold, TP; Shireman, BT Substituted 2-azabicycles and their use as orexin receptor modulators US Patent  US8969352 Publication Date 3/3/2015 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM143761
Synonyms:
US10183953, Example 25 | US8969352, 22 | US8969352, 23 | US8969352, 24 | US8969352, 25 | US9611277, Example 25 | US9845333, 25
Type:
Small organic molecule
Emp. Form.:
C21H19F3N6O2
Mol. Mass.:
444.4098
SMILES:
Cc1ccc(c(n1)C(=O)N1CC2CC(Oc3ccc(cn3)C(F)(F)F)C1C2)-n1nccn1 |TLB:14:13:9.10:26,7:9:13.12:26|
Structure:
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