Reaction Details Report a problem with these data
Target
Phosphodiesterase
Ligand
BDBM144396
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
IC50
0.13±n/a nM
Comments
extracted
Citation
 Kawanishi, E; Hongu, M; Tanaka, Y Pyrazolopyrimidine compounds and their use as PDE10 inhibitors US Patent  US8969376 Publication Date 3/3/2015 
Target
Name:
Phosphodiesterase
Synonyms:
Phosphodiesterase 10A (PDE10A)
Type:
Protein
Mol. Mass.:
81617.01
Organism:
Bos taurus (Bovine)
Description:
F1MPW5
Residue:
711
Sequence:
WFGEEAWEGCSVARNLCPPYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCVFIPPGIKEGKPKLIPAGPIAQGTTTSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFRLSHQEVATANLAWASVAIHQVQVCRVFISRDVIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKLSGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTAEEWQGLMHFNLPGRLCKEIELFHFDVGPFENMWPGIFVYMIHRSCGTACFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNSRGLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTRLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQIFPATEPLLKACRNNLSQWEKVIRGEESALGIPDLPEAEGSPERLPVKTDD
  
Inhibitor
Name:
BDBM144396
Synonyms:
US8969376, 1.027
Type:
Small organic molecule
Emp. Form.:
C22H22F3N7O
Mol. Mass.:
457.4516
SMILES:
Cc1nc2ccccc2nc1-c1cc2nc(cc(NC[C@H](O)C(F)(F)F)n2n1)N1CCCC1 |r|
Structure:
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