Reaction Details Report a problem with these data
Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM145835
Substrate
n/a
Meas. Tech.
Homogeneous Time Resolved Fluorescence Assay
Ki
1.4±n/a nM
Citation
 Chai, W; Dvorak, CA; Eccles, W; Edwards, JP; Goldberg, SD; Krawczuk, PJ; Lebsack, AD; Liu, J; Pippel, DJ; Sales, ZS; Tanis, VM; Tichenor, MS; Wiener, JJ 1,2,6-substituted benzimidazoles as FLAP modulators US Patent  US8952177 Publication Date 2/10/2015 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase-activating protein (FLAP) | A0A087WW23_HUMAN | ALOX5AP
Type:
Protein
Mol. Mass.:
24212.61
Organism:
Homo sapiens (Human)
Description:
A0A087WW23
Residue:
218
Sequence:
MLTFNHDAPWHTQKTLKTSEFGKSFGTLGHIGNISHQCWAGCAAGGRAVLSGEPEANMDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM145835
Synonyms:
US8952177, 2 | US9695149, 2
Type:
Small organic molecule
Emp. Form.:
C28H28BrN3O3
Mol. Mass.:
534.444
SMILES:
Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)nc1
Structure:
Search PDB for entries with ligand similarity: