Reaction Details
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5-hydroxytryptamine receptor 5A
Ligand
BDBM148166
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.4±n/a
Temperature
310.15±n/a K
Ki
2.7±n/a nM
Comments
extracted
Citation
Hamaguchi, W; Kinoyama, I; Koganemaru, Y; Miyazaki, T; Kaneko, O; Sekioka, R; Washio, T Tetrahydroisoquinoline derivative US Patent US8962612 Publication Date 2/24/2015 More Info.:
Target
Name:
5-hydroxytryptamine receptor 5A
Synonyms:
5-HT-5 | 5-HT-5A | 5-hydroxytryptamine receptor 5 (5-HT5) | 5-hydroxytryptamine receptor 5A (5-HT5A) | 5HT5A_HUMAN | HTR5A | Serotonin (5-HT) receptor | Serotonin receptor 5A
Type:
Enzyme
Mol. Mass.:
40266.25
Organism:
Homo sapiens (Human)
Description:
P47898
Residue:
357
Sequence:
MDLPVNLTSFSLSTPSPLETNHSLGKDDLRPSSPLLSVFGVLILTLLGFLVAATFAWNLLVLATILRVRTFHRVPHNLVASMAVSDVLVAALVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHMEYTLRTRKCVSNVMIALTWALSAVISLAPLLFGWGETYSEGSEECQVSREPSYAVFSTVGAFYLPLCVVLFVYWKIYKAAKFRVGSRKTNSVSPISEAVEVKDSAKQPQMVFTVRHATVTFQPEGDTWREQKEQRAALMVGILIGVFVLCWIPFFLTELISPLCSCDIPAIWKSIFLWLGYSNSFFNPLIYTAFNKNYNSAFKNFFSRQH
Inhibitor
Name:
BDBM148166
Synonyms:
US8962612, 76
Type:
Small organic molecule
Emp. Form.:
C16H19FN4O
Mol. Mass.:
302.3467
SMILES:
[#7]\[#6](-[#7])=[#7]\[#6](=O)-[#7]-1-[#6]-c2c(ccc(F)c2C2([#6]-[#6]2)[#6]-1)-[#6]-1-[#6]-[#6]-1
Structure:
