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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM149684
Substrate
n/a
Meas. Tech.
Kinase Inhibition Assay
pH
7.5±n/a
IC50
>10000±n/a nM
Comments
extracted
Citation
 Caldarelli, M; Angiolini, M; Beria, I; Brasca, MG; Casuscelli, F; D'Alessio, R; Lombardi Borgia, A Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors US Patent  US8975267 Publication Date 3/10/2015 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM149684
Synonyms:
US8975267, 3
Type:
Small organic molecule
Emp. Form.:
C39H49N7O2
Mol. Mass.:
647.8521
SMILES:
CCc1cccc(CC)c1NC(=O)c1c(C)n(C)c-2c1CCc1cnc(Nc3ccc(cc3OC)N3CCC(CC3)N3CCCC3)nc-21
Structure:
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