Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM150300
Substrate
n/a
Meas. Tech.
ThermoFluor Assay
Kd
1.4±0.6 nM
Citation
 Connelly, M; Flores, CM; Macielag, MJ Monoacylglycerol lipase inhibitors for the treatment of metabolic diseases and related disorders US Patent  US8987247 Publication Date 3/24/2015 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM150300
Synonyms:
US8987247, 1
Type:
Small organic molecule
Emp. Form.:
C26H24FN5O2S
Mol. Mass.:
489.564
SMILES:
Fc1ccc(cc1)-n1ccc2cc(ccc12)C(=O)N1CC(C1)N1CCN(CC1)C(=O)c1nccs1
Structure:
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