Reaction Details Report a problem with these data
Target
Cathepsin H
Ligand
BDBM150780
Substrate
n/a
Meas. Tech.
Cathepsin Ezyme Assay
pH
6±n/a
Ki
2.5e+3±n/a nM
Comments
extracted
Citation
 Singh, M; Raghav, N 2,3-Dihydroquinazolin-4(1H)-one derivatives as potential non-peptidyl inhibitors of cathepsins B and H. Bioorg Chem 59:12-22 (2015) [PubMed]  Article 
Target
Name:
Cathepsin H
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
37394.24
Organism:
Capra hircus (Goat)
Description:
A0A060INS8
Residue:
335
Sequence:
MWAVLPLLCAGAWLLGAPACGAAELAVNSLEKFHFQSWMVQHQKKYSSEEYHHRLQVFASNLREINAHNARNHTFKMGLNQFSDMSFAELKRKYLWSEPQNCSATKSNYLRGTGPYPPSMDWREKGNFVTPVKNQGSCGSCWTFSTTGALESAVAIATGKLPFLAEQQLVDCAQNFNNHGCQGGLPSQAFEYIRYNKGIMGEDTYPYRGQDGDCKYQPSKAIAFVKDVANITLNDEEAMVEAVALYNPVSFAFEVTADFMMYRKGIYSSTSCHKTPDKVNHAVLAVGYGEEKGIPYWIVKNSWGPHWGMKGYFLIERGKNMCGLAACASFPIPLV
  
Inhibitor
Name:
BDBM150780
Synonyms:
2-(4-Methylphenyl)-2,3-dihydroquinazolin-4(1H)-one (1c)
Type:
Small organic molecule
Emp. Form.:
C15H14N2O
Mol. Mass.:
238.2845
SMILES:
Cc1ccc(cc1)C1NC(=O)c2ccccc2N1
Structure:
Search PDB for entries with ligand similarity: