Reaction Details
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Acetylcholinesterase
Ligand
BDBM152512
Substrate
n/a
Meas. Tech.
In Vitro AChE Inhibition Assay
pH
8±n/a
Ki
1.577e+4± 3e+1 nM
IC50
5.728e+4± 4e+1 nM
Km
1160±2260 nM
Comments
extracted
Citation
Piplani, P; Danta, CC Design and synthesis of newer potential 4-(N-acetylamino)phenol derived piperazine derivatives as potential cognition enhancers. Bioorg Chem 60:64-73 (2015) [PubMed] Article More Info.:
Target
Name:
Acetylcholinesterase
Synonyms:
ACES_MOUSE | Acetylcholinesterase (AChE) | Acetylcholinesterase (mouse AChE) | Acetylcholinesterase precursor | Ache
Type:
Enzyme
Mol. Mass.:
68165.65
Organism:
Mus musculus (mouse)
Description:
n/a
Residue:
614
Sequence:
MRPPWYPLHTPSLAFPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYSKQERCSDL
Inhibitor
Name:
BDBM152512
Synonyms:
N-[4-{2-(4-ethylpiperazin-1-yl)-2-oxoethoxy}phenyl]acetamide (1a)
Type:
Small organic molecule
Emp. Form.:
C16H23N3O3
Mol. Mass.:
305.3721
SMILES:
CCN1CCN(CC1)C(=O)COc1ccc(NC(C)=O)cc1
Structure:
