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Target
Chitin synthase 3
Ligand
BDBM152550
Substrate
n/a
Meas. Tech.
Chitin Synthase Assays
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
8.00e+5±n/a nM
Comments
extracted
Citation
 Kral, K; Bieg, T; Nawrot, U; Wlodarczyk, K; Lalik, A; Hahn, P; Wandzik, I New monomeric and dimeric uridinyl derivatives as inhibitors of chitin synthase. Bioorg Chem 61:13-20 (2015) [PubMed]  Article 
Target
Name:
Chitin synthase 3
Synonyms:
CAL1 | CHS3 | CHS3_YEAST | CSD2 | Chitin synthase (CS) | DIT101 | KIT2
Type:
Protein
Mol. Mass.:
131602.23
Organism:
Saccharomyces cerevisiae (Yeast)
Description:
P29465
Residue:
1165
Sequence:
MTGLNGDDPDDYYLNLNQDEESLLRSRHSVGSGAPHRQGSLVRPERSRLNNPDNPHFYYAQKTQEQMNHLDVLPSSTGVNPNATRRSGSLRSKGSVRSKFSGRETDSYLLQDMNTTDKKASVKISDEGVAEDEFDKDGDVDNFEESSTQPINKSIKPLRKETNDTLSFWQMYCYFITFWAPAPILAFCGMPKKERQMAWREKVALISVILYIGAIVAFLTFGFTKTVCSSSKLRLKNNEVSTEFVVINGKAYELDTSSRSGIQDVEVDSDTLYGPWSDAGKDASFLFQNVNGNCHNLITPKSNSSIPHDDDNNLAWYFPCKLKNQDGSSKPNFTVENYAGWNCHTSKEDRDAFYGLKSKADVYFTWDGIKNSSRNLIVYNGDVLDLDLLDWLEKDDVDYPVVFDDLKTSNLQGYDLSLVLSNGHERKIARCLSEIIKVGEVDSKTVGCIASDVVLYVSLVFILSVVIIKFIIACYFRWTVARKQGAYIVDNKTMDKHTNDIEDWSNNIQTKAPLKEVDPHLRPKKYSKKSLGHKRASTFDLLKKHSSKMFQFNESVIDLDTSMSSSLQSSGSYRGMTTMTTQNAWKLSNENKAVHSRNPSTLLPTSSMFWNKATSSPVPGSSLIQSLDSTIIHPDIVQQPPLDFMPYGFPLIHTICFVTCYSEDEEGLRTTLDSLSTTDYPNSHKLLMVVCDGLIKGSGNDKTTPEIALGMMDDFVTPPDEVKPYSYVAVASGSKRHNMAKIYAGFYKYDDSTIPPENQQRVPIITIVKCGTPAEQGAAKPGNRGKRDSQIILMSFLEKITFDERMTQLEFQLLKNIWQITGLMADFYETVLMVDADTKVFPDALTHMVAEMVKDPLIMGLCGETKIANKAQSWVTAIQVFEYYISHHQAKAFESVFGSVTCLPGCFSMYRIKSPKGSDGYWVPVLANPDIVERYSDNVTNTLHKKNLLLLGEDRFLSSLMLKTFPKRKQVFVPKAACKTIAPDKFKVLLSQRRRWINSTVHNLFELVLIRDLCGTFCFSMQFVIGIELIGTMVLPLAICFTIYVIIFAIVSKPTPVITLVLLAIILGLPGLIVVITATRWSYLWWMCVYICALPIWNFVLPSYAYWKFDDFSWGDTRTIAGGNKKAQDENEGEFDHSKIKMRTWREFEREDILNRKEESDSFVA
  
Inhibitor
Name:
BDBM152550
Synonyms:
5'-(N-succinyl)-5'-amino-5'-deoxyuridine methyl ester (7)
Type:
Small organic molecule
Emp. Form.:
C14H19N3O8
Mol. Mass.:
357.316
SMILES:
COC(=O)CCC(=O)NC[C@H]1O[C@H]([C@@H](O)C1O)n1ccc(=O)[nH]c1=O |r|
Structure:
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