Reaction Details Report a problem with these data
Target
Beta-lactamase [24-383]
Ligand
BDBM152694
Substrate
n/a
Meas. Tech.
Steady State Kinetics Assays
pH
7.4±0
Temperature
298.15±0 K
Ki
21.1±1.9 nM
Kd
90±0.0 nM
Citation
 Powers, RA; Swanson, HC; Taracila, MA; Florek, NW; Romagnoli, C; Caselli, E; Prati, F; Bonomo, RA; Wallar, BJ Biochemical and structural analysis of inhibitors targeting the ADC-7 cephalosporinase of Acinetobacter baumannii. Biochemistry 53:7670-9 (2014) [PubMed]  Article 
Target
Name:
Beta-lactamase [24-383]
Synonyms:
ADC-7 beta-lactamase (ADC-7)
Type:
Protein
Mol. Mass.:
40642.04
Organism:
Acinetobacter baumannii (g-Proteobacteria)
Description:
A version of ADC-7 starting at amino acid 24.
Residue:
360
Sequence:
DNTPKDQEIKKLVDQNFKPLLEKYDVPGMAVGVIQNNKKYEMYYGLQSVQDKKAVNSNTIFELGSVSKLFTATAGGYAKNKGKISFDDTPGKYWKELKNTPIDQVNLLQLATYTSGNLALQFPDEVQTDQQVLTFFKDWKPKNPIGEYRQYSNPSIGLFGKVVALSMNKPFDQVLEKTIFPALGLKHSYVNVPKTQMQNYAFGYNQENQPIRVNPGPLDAPAYGVKSTLPDMLSFIHANLNPQKYPTDIQRAINETHQGRYQVNTMYQALGWEEFSYPATLQTLLDSNSEQIVMKPNKVTAISKEPSVKMYHKTGSTSGFGTYVVFIPKENIGLVMLTNKRIPNEERIKAAYVVLNAIKK
  
Inhibitor
Name:
BDBM152694
Synonyms:
SM23
Type:
Small organic molecule
Emp. Form.:
C14H14BNO5S
Mol. Mass.:
319.141
SMILES:
OB(O)[C@@H](NC(=O)Cc1cccs1)c1cccc(c1)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: