Reaction Details Report a problem with these data
Target
Nitric oxide synthase oxygenase
Ligand
BDBM50427862
Substrate
n/a
Meas. Tech.
Imidazole Spin Shift Assay
Kd
4.47e+3± 3.6e+2 nM
Citation
 Holden, JK; Dejam, D; Lewis, MC; Huang, H; Kang, S; Jing, Q; Xue, F; Silverman, RB; Poulos, TL Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase. Biochemistry 54:4075-82 (2015) [PubMed]  Article 
Target
Name:
Nitric oxide synthase oxygenase
Synonyms:
NOSO_BACSU | Nitric oxide synthase (bsNOS) | nos | yflM
Type:
Protein
Mol. Mass.:
41892.66
Organism:
Bacillus subtilis (Firmicutes)
Description:
O34453
Residue:
363
Sequence:
MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGSYVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATNNGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGWRGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPIISDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLWKDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPISPAATHIFHRSYDNSIVKPNYFYQDKPYE
  
Inhibitor
Name:
BDBM50427862
Synonyms:
CHEMBL2326361
Type:
Small organic molecule
Emp. Form.:
C23H25N5
Mol. Mass.:
371.4781
SMILES:
Cc1cc(N)nc(CCc2cc(CCc3cc(C)cc(N)n3)cc(c2)C#N)c1
Structure:
Search PDB for entries with ligand similarity: