Reaction Details Report a problem with these data
Target
Nitric oxide synthase oxygenase
Ligand
BDBM50438639
Substrate
n/a
Meas. Tech.
Imidazole Spin Shift Assay
Kd
2.37e+5± 2.4e+4 nM
Citation
 Holden, JK; Dejam, D; Lewis, MC; Huang, H; Kang, S; Jing, Q; Xue, F; Silverman, RB; Poulos, TL Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase. Biochemistry 54:4075-82 (2015) [PubMed]  Article 
Target
Name:
Nitric oxide synthase oxygenase
Synonyms:
NOSO_BACSU | Nitric oxide synthase (bsNOS) | nos | yflM
Type:
Protein
Mol. Mass.:
41892.66
Organism:
Bacillus subtilis (Firmicutes)
Description:
O34453
Residue:
363
Sequence:
MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGSYVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATNNGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGWRGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPIISDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLWKDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPISPAATHIFHRSYDNSIVKPNYFYQDKPYE
  
Inhibitor
Name:
BDBM50438639
Synonyms:
CHEMBL2414437 | US9732037, Compound 5
Type:
Small organic molecule
Emp. Form.:
C21H23FN4O
Mol. Mass.:
366.4319
SMILES:
Cc1cc(N)nc(COc2cncc(CNCCc3cccc(F)c3)c2)c1
Structure:
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