Reaction Details Report a problem with these data
Target
Nitric oxide synthase oxygenase
Ligand
BDBM152714
Substrate
n/a
Meas. Tech.
Imidazole Spin Shift Assay
Kd
2.23e+4± 8e+2 nM
Citation
 Holden, JK; Dejam, D; Lewis, MC; Huang, H; Kang, S; Jing, Q; Xue, F; Silverman, RB; Poulos, TL Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase. Biochemistry 54:4075-82 (2015) [PubMed]  Article 
Target
Name:
Nitric oxide synthase oxygenase
Synonyms:
NOSO_BACSU | Nitric oxide synthase (bsNOS) | nos | yflM
Type:
Protein
Mol. Mass.:
41892.66
Organism:
Bacillus subtilis (Firmicutes)
Description:
O34453
Residue:
363
Sequence:
MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGSYVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATNNGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGWRGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPIISDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLWKDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPISPAATHIFHRSYDNSIVKPNYFYQDKPYE
  
Inhibitor
Name:
BDBM152714
Synonyms:
6-(2-{5-[2-(dimethylamino)ethyl]pyridin-3-yl}ethyl)-4-methylpyridin-2-amine (17)
Type:
Small organic molecule
Emp. Form.:
C17H24N4
Mol. Mass.:
284.3993
SMILES:
CN(C)CCc1cncc(CCc2cc(C)cc(N)n2)c1
Structure:
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