Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Cyclin-dependent kinase 2 [F80T]
Ligand
BDBM154576
Substrate
n/a
Meas. Tech.
EMSA
pH
7.5000±n/a
IC50
>1.0e+4±n/a nM
Comments
extracted
Citation
Alexander, LT; Möbitz, H; Drueckes, P; Savitsky, P; Fedorov, O; Elkins, JM; Deane, CM; Cowan-Jacob, SW; Knapp, S Type II Inhibitors Targeting CDK2. ACS Chem Biol 10:2116-25 (2015) [PubMed] Article More Info.:
Target
Name:
Cyclin-dependent kinase 2 [F80T]
Synonyms:
CDK2_HUMAN | CDK2 | CDKN2 | Cyclin-dependent protein kinase 2 (CDK2 F80T)
Type:
Protein
Mol. Mass.:
33892.10
Organism:
Human
Description:
P24941[F80T]
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVTEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Inhibitor
Name:
BDBM154576
Synonyms:
K03861 (1)
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CN1CCN(CC1)Cc2ccc(cc2C(F)(F)F)NC(=O)Nc3ccc(cc3)Oc4ccnc(n4)N
Structure:
