Reaction Details Report a problem with these data
Target
AMP deaminase 1
Ligand
BDBM154584
Substrate
n/a
Meas. Tech.
AMPD Enzymatic Activity Assay
pH
7.4±n/a
IC50
24±n/a nM
Comments
extracted
Citation
 Admyre, T; Amrot-Fors, L; Andersson, M; Bauer, M; Bjursell, M; Drmota, T; Hallen, S; Hartleib-Geschwindner, J; Lindmark, B; Liu, J; Löfgren, L; Rohman, M; Selmi, N; Wallenius, K Inhibition of AMP deaminase activity does not improve glucose control in rodent models of insulin resistance or diabetes. Chem Biol 21:1486-96 (2014) [PubMed]  Article 
Target
Name:
AMP deaminase 1
Synonyms:
AMP deaminase 1 (hAMPD1) | AMP deaminase isoform M | AMPD1 | AMPD1_HUMAN | Myoadenylate deaminase
Type:
Protein
Mol. Mass.:
90225.27
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
780
Sequence:
MNVRIFYSVSQSPHSLLSLLFYCAILESRISATMPLFKLPAEEKQIDDAMRNFAEKVFASEVKDEGGRQEISPFDVDEICPISHHEMQAHIFHLETLSTSTEARRKKRFQGRKTVNLSIPLSETSSTKLSHIDEYISSSPTYQTVPDFQRVQITGDYASGVTVEDFEIVCKGLYRALCIREKYMQKSFQRFPKTPSKYLRNIDGEAWVANESFYPVFTPPVKKGEDPFRTDNLPENLGYHLKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTFLDDMNFLLALIAQGPVKTYTHRRLKFLSSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYQIDADRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASELRDLYLKTDNYINGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSKLSSWFVCNRIHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFMPVFEATINPQADPELSVFLKHITGFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPSYTYYAYYMYANIMVLNSLRKERGMNTFLFRPHCGEAGALTHLMTAFMIADDISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFLEYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSVLQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNVAQIRMAYRYETWCYELNLIAEGLKSTE
  
Inhibitor
Name:
BDBM154584
Synonyms:
4-[4-({[(1R)-1-(isoquinolin-8-yl)ethyl]amino}methyl)phenyl]-2-methoxybenzoic acid (Compound 4)
Type:
Small organic molecule
Emp. Form.:
C26H24N2O3
Mol. Mass.:
412.4804
SMILES:
COc1cc(ccc1C(O)=O)-c1ccc(CN[C@H](C)c2cccc3ccncc23)cc1 |r|
Structure:
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