Reaction Details Report a problem with these data
Target
Enteropeptidase
Ligand
BDBM158115
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
Ki
0.42±n/a nM
Comments
extracted
Citation
 Koshiba, T; Tokumasu, M; Ichimaru, T; Ohsumi, K; Nakagawa, T; Yamada, T; Matsumoto, K; Suzuki, T Heteroarylcarboxylic acid ester derivative US Patent  US9024044 Publication Date 5/5/2015 
Target
Name:
Enteropeptidase
Synonyms:
ENTK | ENTK_HUMAN | PRSS7 | TMPRSS15
Type:
Enzyme
Mol. Mass.:
112901.62
Organism:
Homo sapiens (Human)
Description:
P98073
Residue:
1019
Sequence:
MGSKRGISSRHHSLSSYEIMFAALFAILVVLCAGLIAVSCLTIKESQRGAALGQSHEARATFKITSGVTYNPNLQDKLSVDFKVLAFDLQQMIDEIFLSSNLKNEYKNSRVLQFENGSIIVVFDLFFAQWVSDENVKEELIQGLEANKSSQLVTFHIDLNSVDILDKLTTTSHLATPGNVSIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDEDNKMCATVCDGRFLLTGSSGSFQATHYPKPSETSVVCQWIIRVNQGLSIKLSFDDFNTYYTDILDIYEGVGSSKILRASIWETNPGTIRIFSNQVTATFLIESDESDYVGFNATYTAFNSSELNNYEKINCNFEDGFCFWVQDLNDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQERVGLLSLPLDPTLEPACLSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYGQVTLNETVKFKVAFNAFKNKILSDIALDDISLTYGICNGSLYPEPTLVPTPPPELPTDCGGPFELWEPNTTFSSTNFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENINDVVEIRDGEEADSLLLAVYTGPGPVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQSIWHTACAENWTTQISNDVCQLLGLGSGNSSKPIFPTDGGPFVKLNTAPDGHLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQSFLH
  
Inhibitor
Name:
BDBM158115
Synonyms:
US9024044, 43 | US9227949, 43
Type:
Small organic molecule
Emp. Form.:
C24H28FN3O7S
Mol. Mass.:
521.558
SMILES:
CCC(CC)(Cc1ccc(s1)C(=O)Oc1ccc(cc1F)C(N)=N)C(=O)N[C@H](CCC(O)=O)C(O)=O |r|
Structure:
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