Reaction Details
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Bifunctional ligase/repressor BirA
Ligand
BDBM161469
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
8±n/a
Temperature
310.15±n/a K
Ki
1170±n/a nM
IC50
7000±n/a nM
Comments
extracted
Citation
Abell, A; Polyak, S; Booker, G; Wallace, J; Soares da Costa, T; Jarrad, A; Tieu, W; Keeling, KL; Pedersen, DS; Pendini, N; Wilce, M; Yap, MY Antimicrobial compounds US Patent US9108978 Publication Date 8/18/2015 More Info.:
Target
Name:
Bifunctional ligase/repressor BirA
Synonyms:
Biotin ligase | Biotin protein ligase (BPL)
Type:
Protein
Mol. Mass.:
37140.09
Organism:
Staphylococcus aureus
Description:
W8TTE7
Residue:
323
Sequence:
MSKYSQDVLQLLYKNKPNYISGQSIAESLNISRTAVKKVIDQLKLEGCKIDSVNHKGHLLQQLPDIWYQGIIDQYTKSSALFDFSEVYDSIDSTQLAAKKSLVGNQSSFFILSDEQTKGRGRFNRHWSSSKGQGLWMSVVLRPNVAFSMISKFNLFIALGIRDAIQHFSQDEVKVKWPNDIYIDNGKVCGFLTEMVANNDGIEAIICGIGINLTQQLENFDESIRHRATSIQLHDKNKLDRYQFLERLLQEIEKRYNQFLTLPFSEIREEYIAASNIWNRTLLFTENDKQFKGQAIDLDYDGYLIVRDEAGESHRLISADIDF
Inhibitor
Name:
BDBM161469
Synonyms:
US9108978, 6.07
Type:
Small organic molecule
Emp. Form.:
C26H33N5O2S
Mol. Mass.:
479.638
SMILES:
O=C1N[C@H]2CS[C@@H](CCCCCc3cn(CCCCOc4ccc5ccccc5c4)nn3)[C@H]2N1 |r|
Structure:
