Reaction Details
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Bifunctional ligase/repressor BirA
Ligand
BDBM161471
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
8±n/a
Temperature
310.15±n/a K
Ki
>10000±n/a nM
IC50
>50000±n/a nM
Comments
extracted
Citation
Abell, A; Polyak, S; Booker, G; Wallace, J; Soares da Costa, T; Jarrad, A; Tieu, W; Keeling, KL; Pedersen, DS; Pendini, N; Wilce, M; Yap, MY Antimicrobial compounds US Patent US9108978 Publication Date 8/18/2015 More Info.:
Target
Name:
Bifunctional ligase/repressor BirA
Synonyms:
Biotin ligase | Biotin protein ligase (BPL)
Type:
Protein
Mol. Mass.:
37140.09
Organism:
Staphylococcus aureus
Description:
W8TTE7
Residue:
323
Sequence:
MSKYSQDVLQLLYKNKPNYISGQSIAESLNISRTAVKKVIDQLKLEGCKIDSVNHKGHLLQQLPDIWYQGIIDQYTKSSALFDFSEVYDSIDSTQLAAKKSLVGNQSSFFILSDEQTKGRGRFNRHWSSSKGQGLWMSVVLRPNVAFSMISKFNLFIALGIRDAIQHFSQDEVKVKWPNDIYIDNGKVCGFLTEMVANNDGIEAIICGIGINLTQQLENFDESIRHRATSIQLHDKNKLDRYQFLERLLQEIEKRYNQFLTLPFSEIREEYIAASNIWNRTLLFTENDKQFKGQAIDLDYDGYLIVRDEAGESHRLISADIDF
Inhibitor
Name:
BDBM161471
Synonyms:
US9108978, 6.34
Type:
Small organic molecule
Emp. Form.:
C22H31N3O7PS
Mol. Mass.:
512.537
SMILES:
Cc1ccc2oc(=O)n(CCCCOP([O-])(=O)OCCCCC[C@@H]3SC[C@@H]4NC(=O)N[C@H]34)c2c1 |r|
Structure:
