Reaction Details Report a problem with these data
Target
Bifunctional ligase/repressor BirA
Ligand
BDBM161472
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
8.0000±n/a
Temperature
310.1500±n/a K
Ki
420±n/a nM
Comments
extracted
Citation
 Abell, A; Polyak, S; Booker, G; Wallace, J; Soares da Costa, T; Jarrad, A; Tieu, W; Keeling, KL; Pedersen, DS; Pendini, N; Wilce, M; Yap, MY Antimicrobial compounds US Patent  US9108978 Publication Date 8/18/2015 
Target
Name:
Bifunctional ligase/repressor BirA
Synonyms:
Biotin--[acetyl-CoA-carboxylase] synthetase | Biotin protein ligase (BPL) | Biotin operon repressor | BIRA_ECOLI | birA | bioR | dhbB | BirA Bifunctional Protein
Type:
Repressor protein
Mol. Mass.:
35313.58
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
321
Sequence:
MKDNTVPLKLIALLANGEFHSGEQLGETLGMSRAAINKHIQTLRDWGVDVFTVPGKGYSLPEPIQLLNAKQILGQLDGGSVAVLPVIDSTNQYLLDRIGELKSGDACIAEYQQAGRGRRGRKWFSPFGANLYLSMFWRLEQGPAAAIGLSLVIGIVMAEVLRKLGADKVRVKWPNDLYLQDRKLAGILVELTGKTGDAAQIVIGAGINMAMRRVEESVVNQGWITLQEAGINLDRNTLAAMLIRELRAALELFEQEGLAPYLSRWEKLDNFINRPVKLIIGDKEIFGISRGIDKQGALLLEQDGIIKPWMGGEISLRSAEK
  
Inhibitor
Name:
BDBM161472
Synonyms:
US9108978, 2.02
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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