Reaction Details
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3-oxo-5-alpha-steroid 4-dehydrogenase 2
Ligand
BDBM50269532
Substrate
n/a
Meas. Tech.
In Vitro Inhibition Assay
IC50
14000±n/a nM
Citation
Fouche, G; Maharaj, VJ; Mthembu, X; Ackerman, L; Van Der Merwe, M Management and treatment of benign prostatic hyperplasia US Patent US9061023 Publication Date 6/23/2015 More Info.:
Target
Name:
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Synonyms:
3-oxo-5-alpha-steroid 4-dehydrogenase 2 | 5 alpha-SR2 | 5α-Reductase 2 (5α-R2) | S5A2_HUMAN | SR type 2 | SRD5A2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 | Type II 5-alpha reductase
Type:
Enzyme
Mol. Mass.:
28406.59
Organism:
Homo sapiens (Human)
Description:
P31213
Residue:
254
Sequence:
MQVQCQQSPVLAGSATLVALGALALYVAKPSGYGKHTESLKPAATRLPARAAWFLQELPSFAVPAGILARQPLSLFGPPGTVLLGLFCLHYFHRTFVYSLLNRGRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF
Inhibitor
Name:
BDBM50269532
Synonyms:
(6,9,12)-linolenic acid | (6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid | (Z,Z,Z)-6,9,12-octadecatrienoic acid | CHEMBL464982 | US9061023, gamma-Linolenic acid | all-cis-6,9,12-octadecatrienoic acid | cis-Delta(6,9,12)-octadecatrienoic acid | gamma-linolenic acid | gamolenic acid
Type:
Small organic molecule
Emp. Form.:
C18H30O2
Mol. Mass.:
278.4296
SMILES:
CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O
Structure:
