Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM166438
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
IC50
367180±n/a nM
Comments
extracted
Citation
 Hsieh, P; Hwang, T; Wang, W; Wang, T Oxime-based compound, pharmaceutical composition containing the same and method for preparing the same US Patent  US9073833 Publication Date 7/7/2015 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM166438
Synonyms:
US9073833, 6
Type:
Small organic molecule
Emp. Form.:
C20H24N2O5S
Mol. Mass.:
404.48
SMILES:
CO\N=C(\C)c1ccccc1NS(=O)(=O)c1ccc(OC(=O)C(C)(C)C)cc1
Structure:
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