Reaction Details Report a problem with these data
Target
11-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM167439
Substrate
n/a
Meas. Tech.
Homogenous Time-Resolved Fluorescence (HTRF) Assay
IC50
>10000±n/a nM
Citation
 Kim, KY; Ahn, JH; Kang, SK; Rhee, SD; Bae, MA; Ahn, SH; Kim, HY; Jung, WH; Kang, NS Sulfamide derivative having an adamantyl group and its pharmaceutically acceptable salt US Patent  US9073906 Publication Date 7/7/2015 
Target
Name:
11-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
11-DH2 | 11-beta-HSD2 | 11-beta-Hydroxysteroid Dehydrogenase 2 (11-beta-HSD2) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 2 | 11-beta-hydroxysteroid dehydrogenase type 2 | 11-beta-hydroxysteroid dehydrogenase type 2 (11-beta-HSD2) | Corticosteroid 11-beta-dehydrogenase isozyme 2 | DHI2_HUMAN | HSD11B2 | HSD11K | NAD-dependent 11-beta-hydroxysteroid dehydrogenase | SDR9C3
Type:
Enzyme
Mol. Mass.:
44141.72
Organism:
Homo sapiens (Human)
Description:
Purified recombinant human 11beta-HSD2.
Residue:
405
Sequence:
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALAVLAAAGWIALSRLARPQRLPVATRAVLITGCDSGFGKETAKKLDSMGFTVLATVLELNSPGAIELRTCCSPRLRLLQMDLTKPGDISRVLEFTKAHTTSTGLWGLVNNAGHNEVVADAELSPVATFRSCMEVNFFGALELTKGLLPLLRSSRGRIVTVGSPAGDMPYPCLGAYGTSKAAVALLMDTFSCELLPWGVKVSIIQPGCFKTESVRNVGQWEKRKQLLLANLPQELLQAYGKDYIEHLHGQFLHSLRLAMSDLTPVVDAITDALLAARPRRRYYPGQGLGLMYFIHYYLPEGLRRRFLQAFFISHCLPRALQPGQPGTTPPQDAAQDPNLSPGPSPAVAR
  
Inhibitor
Name:
BDBM167439
Synonyms:
US9073906, 89
Type:
Small organic molecule
Emp. Form.:
C22H27F3N4O4S
Mol. Mass.:
500.534
SMILES:
NC(=O)C12CC3CC(C1)C(NC(=O)CN1CCCN(c4c(F)cc(F)cc4F)S1(=O)=O)C(C3)C2 |TLB:10:9:6:3.4.8,10:9:3.33.8:6.5.32,1:3:6:9.31.32,THB:4:3:9:6.5.32,4:5:9:3.33.8,33:3:6:9.31.32,33:31:6:3.4.8,(9.27,3.3,;8.5,1.97,;9.27,.63,;6.96,1.97,;6.56,3.45,;5.08,3.85,;3.99,2.77,;4.39,1.28,;5.87,.88,;4.07,-.77,;2.74,-1.54,;1.4,-.77,;1.4,.77,;.07,-1.54,;-1.26,-.77,;-1.26,.77,;-2.6,1.54,;-3.93,.77,;-3.93,-.77,;-5.27,-1.54,;-6.6,-.77,;-6.6,.77,;-7.93,-1.54,;-7.93,-3.08,;-9.27,-3.85,;-6.6,-3.85,;-5.27,-3.08,;-3.93,-3.85,;-2.6,-1.54,;-3.37,-2.88,;-1.83,-2.88,;5.25,.21,;4.65,2.53,;6.59,-.13,)|
Structure:
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