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Target
Proteinase-activated receptor 1
Ligand
BDBM169630
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
9800±n/a nM
Comments
extracted
Citation
 Heinelt, U; Wehner, V; Herrmann, M; Schoenafinger, K; Steinhagen, H; Scheiper, B Triazolopyridazines as PAR1 inhibitors, production thereof, and use as medicaments US Patent  US9079906 Publication Date 7/14/2015 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM169630
Synonyms:
US9079906, 84
Type:
Small organic molecule
Emp. Form.:
C20H25F5N6O3S
Mol. Mass.:
524.508
SMILES:
CCOc1nn2c(cc1N(CC)CC)nn(CC(=O)c1cc(OC)cc(c1)S(F)(F)(F)(F)F)c2=N
Structure:
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