Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM173301
Substrate
n/a
Meas. Tech.
FLIPR Assay
pH
7.4±n/a
IC50
12.1±n/a nM
Comments
extracted
Citation
 Alcazar Vaca, MJ; Andres Gil, JI; Letavic, MA; Rudolph, DA; Shireman, BT; Stenne, BM; Ziff, JM P2X7 modulators US Patent  US9096596 Publication Date 8/4/2015 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM173301
Synonyms:
US10323032, Example 37 | US9096596, 37 | US9604982, Example 37
Type:
Small organic molecule
Emp. Form.:
C18H12ClF3N4OS
Mol. Mass.:
424.827
SMILES:
FC(F)(F)c1cccc(C(=O)N2CCc3c(C2)ncnc3-c2nccs2)c1Cl
Structure:
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