Reaction Details Report a problem with these data
Target
Non-secretory ribonuclease
Ligand
BDBM173610
Substrate
n/a
Meas. Tech.
Ribonuclease Activity Assay
Temperature
303.15±n/a K
Ki
2.673e+5± 3.34e+4 nM
IC50
4.093e+5± 1.14e+4 nM
Comments
extracted
Citation
Chatzileontiadou, DS; Parmenopoulou, V; Manta, S; Kantsadi, AL; Kylindri, P; Griniezaki, M; Kontopoulou, F; Telopoulou, A; Prokova, H; Panagopoulos, D; Boix, E; Balatsos, NA; Komiotis, D; Leonidas, DD Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin. Bioorg Chem 63:152-65 (2015) [PubMed] Article
More Info.:
Target
Name:
Non-secretory ribonuclease
Synonyms:
EDN | Eosinophil-derived neurotoxin (EDN) | Non-secretory ribonuclease | RNAS2_HUMAN | RNASE2 | RNAse 2 | RNS2
Type:
Protein
Mol. Mass.:
18364.09
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
161
Sequence:
MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII
Inhibitor
Name:
BDBM173610
Synonyms:
9-[3'-[4-[(Uracil-1-yl)methyl]-1,2,3-triazol-1-yl]-b-D-ribofuranosyl]N6-benzoyladenine (11a)
Type:
Small organic molecule
Emp. Form.:
C24H22N10O6
Mol. Mass.:
546.4949
SMILES:
OC[C@H]1O[C@H](C(O)[C@H]1n1cc(Cn2ccc(=O)[nH]c2=O)nn1)n1cnc2c(NC(=O)c3ccccc3)ncnc12 |r|