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Target
Non-secretory ribonuclease
Ligand
BDBM173614
Substrate
n/a
Meas. Tech.
Ribonuclease Activity Assay
Temperature
303.15±n/a K
Ki
3.651e+5± 4.53e+4 nM
IC50
5.591e+5± 1.34e+4 nM
Comments
extracted
Citation
 Chatzileontiadou, DS; Parmenopoulou, V; Manta, S; Kantsadi, AL; Kylindri, P; Griniezaki, M; Kontopoulou, F; Telopoulou, A; Prokova, H; Panagopoulos, D; Boix, E; Balatsos, NA; Komiotis, D; Leonidas, DD Triazole double-headed ribonucleosides as inhibitors of eosinophil derived neurotoxin. Bioorg Chem 63:152-65 (2015) [PubMed]  Article 
Target
Name:
Non-secretory ribonuclease
Synonyms:
EDN | Eosinophil-derived neurotoxin (EDN) | Non-secretory ribonuclease | RNAS2_HUMAN | RNASE2 | RNAse 2 | RNS2
Type:
Protein
Mol. Mass.:
18364.09
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
161
Sequence:
MVPKLFTSQICLLLLLGLLAVEGSLHVKPPQFTWAQWFETQHINMTSQQCTNAMQVINNYQRRCKNQNTFLLTTFANVVNVCGNPNMTCPSNKTRKNCHHSGSQVPLIHCNLTTPSPQNISNCRYAQTPANMFYIVACDNRDQRRDPPQYPVVPVHLDRII
  
Inhibitor
Name:
BDBM173614
Synonyms:
9-[3'-[4-[(Thymine-1-yl)methyl]-1,2,3-triazol-1-yl]-b-D-ribofuranosyl]adenine (12b)
Type:
Small organic molecule
Emp. Form.:
C18H22N10O5
Mol. Mass.:
458.4313
SMILES:
Cc1cn(Cc2cn(nn2)[C@H]2[C@@H](CO)O[C@H](C2O)N2C=NC3C2N=CN=C3N)c(=O)[nH]c1=O |r,c:21,26,28|
Structure:
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